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KMID : 0388120110200020084
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Journal of Korean Society for the Study of Obesity
2011 Volume.20 No. 2 p.84 ~ p.90
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Associations of Serum Vascular Endothelial Growth Factor and Abdominal Fat Distributions in Obese Korean Women
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Yun Kyung-Eun
Park Hye-Soon
Park Chan-Keum
Song Young-Sook
Jang Yeon-Jin
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Abstract
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Background: Vascular endothelial growth factor (VEGF) is a very potent angiogenic factor expressed and secreted from adipocytes, and VEGF-mediated angiogenesis is necessary for the adipose tissue expansion associated with human obesity. This study investigates the associations of serum VEGF concentration and abdominal fat distributions in obese Korean women.
Methods: A cross-sectional study was conducted in 37 obese women (BMI ≥ 30 kg/m2) who visited the obesity clinic in a tertiary health care center (Seoul, Korea). Anthropometric indices were measured and abdominal fat distribution was assessed by computed tomography. Fasting plasma glucose, insulin, lipid profiles, and serum VEGF concentrations were measured.
Results: Serum VEGF concentration significantly correlated with BMI (r = 0.478, P = 0.024) and visceral fat area (r = 0.449, P = 0.036) after adjustment for age. In multivariate linear regression analysis, visceral fat area was independently associated with serum VEGF concentration in the study subjects.
Conclusion: The present study shows that visceral fat accumulation is independently associated with elevation of serum VEGF concentrations in obese Korean women. This suggests the intriguing possibility that anti-angiogenic components may reduce visceral fat in obese subjects.
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KEYWORD
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VEGF, BMI, Visceral fat accumulation, Obesity
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